![]() ![]() After approximately 24 h, intense vasoconstriction followed by tissue necrosis was noted, which indicated that menstruation was triggered by spiral arteriole coiling. the release of blood), a 4–24 h period of vasoconstriction was observed. The first classical model of menstruation to describe the vascular and endometrial changes was created by transplanting intraocular implants of the human endometrium into Rhesus monkeys ( Markee 1940, 1978). ![]() The vascular response of the spiral arteries is considered to be the initiator of menstruation. Although endometrial bleeding and shedding are important physiological events, the mechanisms underlying menstruation are still unclear. In conclusion, hypoxia is involved but not an essential component of endometrial breakdown during menstruation.ĭuring each menstrual cycle, the functional layer of the human endometrium undergoes extensive breakdown and remodelling under the tight regulation of estrogen and progesterone. Hypoxia significantly enhanced the mRNA expression of specific matrix metalloproteinases ( MMPs) under the conditions of P4 withdrawal. Based on mouse menstrual-like model and experiments with human decidual stromal cells, we observed that P4 withdrawal induced both hypoxia and HIF1 activation however, endometrial breakdown was triggered only by P4 withdrawal. In this study, we not only provide convincing evidence that hypoxia exists during endometrial breakdown, but also further explore the role of hypoxia and hypoxia-inducible factor 1 (HIF1) in this process. However, this theory has been challenged by previous studies that have questioned the function and even the existence of hypoxia during menstruation. According to the classical theory, tissue hypoxia resulting from vasoconstriction of the spiral arteries after progesterone (P4) withdrawal initiates the breakdown of the endometrium at the earliest stage of menstruation. However, molecular mechanisms underlying this phenomenon are still unclear. Here a documentation for helping.Menstruation is a specific physiological phenomenon that occurs in women. * Use the command line for making the script executable : chmod u+x editix.sh make the script executable or inside your window manager changing the permission to "execute". Note : OpenJDK has too many bugs for running editix, use official Java VM from oracle.Įditix.sh* : Starting EditiX XML Editor for a unix/linux and mac os x platformĮditix.bat : Starting EditiX XML Editor for a windows platform. ![]() Open a terminal/console and write " java -version" for checking your current version. Then you may download the ZIP version and run unimailer only from the bin/editix.bat command. If you want to install yourself a Java VM, you need at least a Java VM 8. Windows may complain when running because a Java VM will be installed, it may require an administrator privilege before installing. The default install contains a Java VM version. Note that you can use the zip version for avoiding this message. SmartScreen is a default protection inside Windows 10/11, if it displays a message "Windows protected your PC" about the editix's installation, you can disable it selecting "run anyway". JavaScript DOM API for updating your documents.Drag'n drop for building XSLT documents, inserting a file from the file system.JAXP support for plugging a new parser or a new transformer.Default templates for XML, DTD, XSLT, DocBook, XHTML, XML RelaxNG, MathML, SVG, XSL-FO, ANT.XML Instances Generated by W3C Schema or DTD.Multiple search file (With XPath,Regexp,Text expressions).Relational Databases (any JDBC drivers).Schema Generator (DTD, W3C XML Schema, XML Relax NG) from XML documents.Refactoring (elements, attributes,schema type, template name, variables and parameters).Fully customizable (user preference, application descriptor).Multiple criterias research (attribute,element,namespace.).Context sensitive content assistant based on XML Schema, DTD, XML RelaxNG.Syntax error and document xpath location on-the-fly.XML Databases (eXist, Xindice,XML Berkley db). ![]()
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